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The quality of brushes does make a difference. Natural bristled brushes are best as they are soft to the touch and apply powder blush,face powder,eyeshadow or lipstick most effectively. Synthetic brushes are best to use for eyeshadow base,cream eyeshadows,and concealers. They should all be washed with a gentle foaming cleanser,hair shampoo or just plain soap and water. Squeeze out excess water with a towel,lay flat and air dry.